Nitric Acid → N-[4-(dimethylamino)-2-nitrophenyl]acetamide

HRID 2093041노트

반응식

HRID 2093041 반응식
[CH3:1][N:2]([CH3:13])[C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:12])[CH3:11])=[CH:5][CH:4]=1.[N+:14]([O-])([OH:16])=[O:15].OS(O)(=O)=O>>[CH3:13][N:2]([CH3:1])[C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:12])[CH3:11])=[C:5]([N+:14]([O-:16])=[O:15])[CH:4]=1

참가 물질

4

반응물 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 819684'-Dimethylaminoacetanilide

생성물 1

HCID 4396139N-[4-(dimethylamino)-2-nitrophenyl]acetamide

실험 절차

N-[4-(dimethylamino)phenyl]acetamide obtained in step I above was nitrated using nitric acid (1.2 eq)+H2SO4 (1.0 eq) at 0 to 5° C. for 2 hrs. After the completion of the reaction, reaction mixture was added to ice and pH was adjusted to 8, extracted with dichloromethane, which was evaporated to dryness to obtain N-[4-(dimethylamino)-2-nitrophenyl]acetamide.

후처리

  1. customat 0 to 5° C.
  2. customfor 2 hrs
  3. customAfter the completion of the reaction, reaction mixture
  4. additionwas added to ice and pH
  5. extractionextracted with dichloromethane, which
  6. customwas evaporated to dryness

출처 및 근거

ORD 기록
ord-d2a14774e774469797592a2ed1dfd384
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08440830B2

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