HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-Bromo-2-nitroaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | N-(4-bromo-2-nitrophenyl)acetamide | HCID 136690 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Bromo-2-nitroaniline | HCID 70132 | 95% |
Reaction Steps
To a solution of N-(4-bromo-2-nitrophenyl)acetamide obtained in step H above (1.0 eq) in MeOH and water was added KOH (1.5 eq) at room temperature and stirred for 5 hrs. Water was added to the reaction mixture and the organic layer was separated, dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford crude product, which, on purification by column chromatography afforded the desired 4-bromo-2-nitroaniline. (Yield=95%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08440830B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-26db4a7f79844a6789453d0b1344a46b |
| Source note | uspto-grants-2013_05 |