HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-(4-nitrophenyl)pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | p-Fluoronitrobenzene | HCID 9590 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 1-(4-nitrophenyl)pyrrolidine | HCID 352305 | 85% |
Reaction Steps
To a solution of 4-fluoronitrobenzene (1.0 eq.) in isopropyl alcohol, pyrrolidine (2.2 eq) and triethylamine (11.0 eq) were added and reaction mixture was refluxed overnight. Reaction mixture was cooled to room temperature, product obtained was collected by filtration and dried to get the desired 1-(4-nitrophenyl)pyrrolidine. (Yield=85%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08440830B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-fea6496eb3754fd8ac6e77eadcb461c1 |
| Source note | uspto-grants-2013_05 |