Nitric Acid → HCID 66863819, compound

HRID 2093049Notes

Reaction equation

HRID 2093049 reaction equation
[N:1]1([C:6]2[CH:11]=[CH:10][C:9]([NH:12][C:13](=[O:15])[CH3:14])=[CH:8][CH:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[N+:16]([O-])([OH:18])=[O:17].OS(O)(=O)=O>>[N+:16]([C:10]1[CH:11]=[C:6]([N:1]2[CH2:2][CH2:3][CH2:4][CH2:5]2)[CH:7]=[CH:8][C:9]=1[NH:12][C:13](=[O:15])[CH3:14])([O-:18])=[O:17]

Participants

4

Reactant 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 1480263N-(4-(Pyrrolidin-1-yl)phenyl)acetamide

Product 1

HCID 66863819HCID 66863819, compound

Procedure

N-(4-Pyrrolidin-1-ylphenyl)acetamide obtained in step III above was nitrated using nitric acid (1.2 eq)+H2SO4 (1.0 eq) at 0 to 5° C. for 2 hrs. After the completion of the reaction, reaction mixture was added to ice and pH was adjusted to 8, extracted with dichloromethane, which was evaporated to dryness to obtain N-(2-nitro-4-pyrrolidin-1-ylphenyl)acetamide

Workup

  1. customat 0 to 5° C.
  2. customfor 2 hrs
  3. customAfter the completion of the reaction, reaction mixture
  4. additionwas added to ice and pH
  5. extractionextracted with dichloromethane, which
  6. customwas evaporated to dryness

Sources & evidence

ORD record
ord-e319c41a785b48ad8e84442ce1dd5af9
Source dataset
uspto-grants-2013_05
Patent number
US08440830B2

Reaction notes

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