HCID 66865281, compound → HCID 66864839, compound

HRID 2093051Notes

Reaction equation

HRID 2093051 reaction equation
[N+:1]([C:4]1[CH:9]=[C:8]([N:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)[CH:7]=[CH:6][C:5]=1[NH:15][C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19])([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:9]=[C:8]([N:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)[CH:7]=[CH:6][C:5]=1[NH:15][C:16](=[O:22])[O:17][C:18]([CH3:20])([CH3:19])[CH3:21]

Participants

4

Reactant 1

HCID 66865281HCID 66865281, compound

Product 1

HCID 66864839HCID 66864839, compoundYield 90%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of tert-butyl 2-nitro-4-pyrrolidin-1-ylphenylcarbamate obtained in step VI above (1.0 eq) in MeOH was hydrogenated using Pd/C under H2 atmosphere. After completion of the reaction, reaction mixture was filtered through celite and evaporated to dryness to get desired tert-butyl 2-amino-4-pyrrolidin-1-ylphenylcarbamate. (Yield=90%)

Workup

  1. customAfter completion of the reaction, reaction mixture
  2. filtrationwas filtered through celite
  3. customevaporated to dryness

Sources & evidence

ORD record
ord-eae843f434f34bcd92fa641eb61c14eb
Source dataset
uspto-grants-2013_05
Patent number
US08440830B2

Reaction notes

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