Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → n-(2-Aminophenyl)-5-(anilinocarbonothioyl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Phenyl Isothiocyanate | HCID 7673 | — |
| 반응물 | N-(2-aminophenyl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide | HCID 58117006 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | n-(2-Aminophenyl)-5-(anilinocarbonothioyl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide | HCID 87183260 | — |
반응 단계
To a solution of N-(2-aminophenyl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide. obtained in step VIII of Example 1 (1 eq) in dichloromethane, a solution of isothiocynato benzene (1 eq) in dichloromethane was added and the reaction was stirred at room temperature for 3 h. Water was added and the organic layer was separated, dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford crude product, which, on purification by column chromatography afforded the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08440830B2 |
| 출처 데이터셋 | uspto-grants-2013_05 |
| ORD ID | ord-8aee5f76cf0a4e73864aff009a987b4e |
| 출처 메모 | uspto-grants-2013_05 |