HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2093076Generated: November 1, 2026
2-Chloropyrimidine → N-(2-aminophenyl)-5-pyrimidin-2-yl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide
https://huagongshe.com/reaction/2093076
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Chloropyrimidine | HCID 74404 | — |
| Reactant | N-(2-aminophenyl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide | HCID 58117006 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-(2-aminophenyl)-5-pyrimidin-2-yl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide | HCID 66864844 | — |
Reaction Steps
To a solution of 2-chloro pyrimidine (1.2 eq) in DMF, N-(2-aminophenyl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide obtained from step VIII of example I (1.0 eq) was added and the reaction mixture was stirred at 100° C. for 15 h. Solvent was then evaporated under reduced pressure to afford crude product, which, on purification by column chromatography or preparative HPLC afforded the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08440830B2 |
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| Source dataset | uspto-grants-2013_05 |
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| ORD ID | ord-2a70e22399a64089b1d096769668adb6 |
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| Source note | uspto-grants-2013_05 |
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