Sodium Hydroxide → HCID 66864421, compound

HRID 2093080Notes

Reaction equation

HRID 2093080 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]2[CH2:16][CH2:15][C:14]3[S:17][C:18]([C:20]([O:22]CC)=[O:21])=[CH:19][C:13]=3[CH2:12]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]2[CH2:16][CH2:15][C:14]3[S:17][C:18]([C:20]([OH:22])=[O:21])=[CH:19][C:13]=3[CH2:12]2)(=[O:9])=[O:10])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 66864775HCID 66864775, compound

Product 1

HCID 66864421HCID 66864421, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of ethyl 5-[(4-methylphenyl)sulfonyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate (1 eq) obtained from step B1 and NaOH (1.5 eq.) in ethanol was refluxed for 2 h. Reaction mixture was concentrated under reduced pressure and neutralized to get 5-[(4-methylphenyl)sulfonyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid.

Workup

  1. customReaction mixture
  2. concentrationwas concentrated under reduced pressure

Sources & evidence

ORD record
ord-a28c665f0dd945e2b75378dca7fe8c10
Source dataset
uspto-grants-2013_05
Patent number
US08440830B2

Reaction notes

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