HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → methyl 4H,5H,6H,7H-thieno[3,2-c]pyridine-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid | HCID 14254906 | — |
| Product | methyl 4H,5H,6H,7H-thieno[3,2-c]pyridine-2-carboxylate | HCID 18697868 | — |
Reaction Steps
To a solution of 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid (1 eq) obtained in step IV in methanol was added thionyl chloride (1.5 eq) at 0° C., and the reaction was refluxed for 3.0 h Reaction mixture was concentrated and neutralized to afforded the methyl 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08440830B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-68e2ae476958492bb1f66b27d5b50ece |
| Source note | uspto-grants-2013_05 |