HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2093092Generated: November 2, 2026
Triethylamine → N2-(2-aminophenyl)-N5-pyridin-3-yl-6,7-dihydrothieno[3,2-c]pyridine-2,5(4H)-dicarboxamide
https://huagongshe.com/reaction/2093092
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Phenyl pyridin-3-ylcarbamate | HCID 6935890 | — |
| Reactant | N-(2-aminophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxamide | HCID 58117019 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N2-(2-aminophenyl)-N5-pyridin-3-yl-6,7-dihydrothieno[3,2-c]pyridine-2,5(4H)-dicarboxamide | HCID 25231181 | — |
Reaction Steps
To a solution of N-(2-aminophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxamide (1.0 eq) obtained in step VIII in DMF was treated with Pyridin-3-yl-carbamic acid phenyl ester (1.0 eq) in presence of base like Et3N and stirred at 50° C. for 8 h Reaction was then quenched with water and extracted with ethyl acetate and the organic layer was separated, dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford crude product, which, on purification by column chromatography afforded the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08440830B2 |
|---|
| Source dataset | uspto-grants-2013_05 |
|---|
| ORD ID | ord-a13f3e2878a64fa6831d376bbfc519c2 |
|---|
| Source note | uspto-grants-2013_05 |
|---|
