HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-(3-nitropyridin-4-yl)-2-oxopropanoate → ethyl 1H-pyrrolo[2,3-c]pyridine-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-(3-nitropyridin-4-yl)-2-oxopropanoate | HCID 23269548 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | ethyl 1H-pyrrolo[2,3-c]pyridine-2-carboxylate | HCID 21819001 | — |
Reaction Steps
To a solution of ethyl 3-(3-nitropyridin-4-yl)-2-oxopropanoate (1.0 eq) in dichloromethane was added 10% Pd/C (1.5 eq.) under nitrogen atmosphere at 110 psi in an autoclave for 48 hrs. Reaction mixture was filtered through celite and concentrated to get brown solid, which, on purification by column chromatography afforded the desired ethyl 1H-pyrrolo[2,3-c]pyridine-2-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08440830B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-dafef5efb481407d8fff78d552dac176 |
| Source note | uspto-grants-2013_05 |