ethyl 6-benzyl-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate → HCID 20158234, compound

HRID 2093107Notes

Reaction equation

HRID 2093107 reaction equation
C([N:8]1[CH2:13][CH2:12][C:11]2[CH:14]=[C:15]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[NH:16][C:10]=2[CH2:9]1)C1C=CC=CC=1>C(O)C.[Pd]>[NH:16]1[C:10]2[CH2:9][NH:8][CH2:13][CH2:12][C:11]=2[CH:14]=[C:15]1[C:17]([O:19][CH2:20][CH3:21])=[O:18]

Participants

4

Reactant 1

HCID 66864599ethyl 6-benzyl-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate

Product 1

HCID 20158234HCID 20158234, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of ethyl 6-benzyl-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate (1.0 eq) in ethanol was added 10% Pd/C (w/w), and the reaction was carried under hydrogen atmosphere overnight. Reaction mixture was filtered through celite and concentrated to afford crude product which on purification afforded compound ethyl 4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate.

Workup

  1. customReaction mixture
  2. filtrationwas filtered through celite
  3. concentrationconcentrated
  4. customto afford crude product which
  5. customon purification

Sources & evidence

ORD record
ord-3af90b75102643aaa7962cfbf226614f
Source dataset
uspto-grants-2013_05
Patent number
US08440830B2

Reaction notes

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