Iodine → HCID 67065998, compound

HRID 2093134Notes

Reaction equation

HRID 2093134 reaction equation
[I:1]I.[CH3:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:17])=[C:7]([F:18])[CH:6]=1>CO.S([O-])([O-])(=O)=O.[Ag+2]>[CH3:3][O:4][C:5]1[C:10]([I:1])=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH3:17])=[C:7]([F:18])[CH:6]=1

Participants

5

Reactant 2

HCID 807IodineHCID 670659662-Fluoro-4-methoxy-1-(2-methylphenyl)benzene

Product 1

HCID 67065998HCID 67065998, compound

Reagents, catalysts & solvents 2

HCID 178418844HCID 178418844, compoundCatalystHCID 887MethanolSolvent2×

Procedure

To a mixture of silver sulfate (0.34 g, 1.11 mmol), iodine (0.28 g, 1.11 mmol) in MeOH (10 ml) at room temperature, a solution of 2-fluoro-2′-methylbiphenyl-4-yl methyl ether from above (0.24 g, 1.11 mmol) in MeOH (5 ml) was added dropwise. The mixture was stirred at room temperature for 4 h until the color turned to light yellow. The solid was filtered off and the filtrate was concentrated. The residue was purified via flash column using hexane as the eluant to give the title compound.

Workup

  1. filtrationThe solid was filtered off
  2. concentrationthe filtrate was concentrated
  3. customThe residue was purified via flash column

Sources & evidence

ORD record
ord-b800a9ce8e5941d48ceb126f2b9c305e
Source dataset
uspto-grants-2013_05
Patent number
US08440702B2

Reaction notes

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