Sodium Carbonate → methyl 2''-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-2,6'-difluoro-4'-methoxy-4''-(trifluoromethyl)-1,1':3',1''-terphenyl-4-carboxylate

Participants

Reaction Steps

methyl 2,2′-difluoro-5′-iodo-4′-methoxybiphenyl-4-carboxylate (100 mg, 0.247 mmol), (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-3-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)benzyl]-1,3-oxazolidin-2-one (INTERMEDIATE 9, 179.2 mg, 0.30 mmol), sodium carbonate (247 μL, aq., 2M, 0.494 mmol), 1,1′-bis(diphenylphosphino)ferrocene-palladium dichloride dichloromethane adduct (40 mg, 0.049 mmol) and 1,4-dioxane (2.1 ml) were heated in a 80° C. oil bath for 8 hours. Aliquot indicated formation of the desired product. Crude mixture was concentrated under reduced pressure. The pot residue was worked up w/H2O/EtOAc/Na2SO4/filtration followed by concentration to afford a dark oil. This oil was purified by a by reverse-phase prep-HPLC (Waters SunFire PrepC18 OBD 5μ, 30×100 mm) eluting w/a MeCN (0.05% TFA, v/v)/H2O (0.05% TFA, v/v) gradient mixture (10 to 100% in 12 min, hold 100% for 3 min) Related fractions were pooled & evaporated in vacuo to afford a dark oil. The oil was further purified by SiO2 (Prep-TLC 30% EtOAc/hex) to afford the title compound. LCMS (ESI) calc.=747.15; found=748.20 (M+1)+.

Provenance & Evidence