Potassium Carbonate → HCID 67454766, compound

Participants

Reaction Steps

A mixture of 0.40 g (1.21 mmol) of 2-amino-4-chloro-6-phenylpyrimidine-5-carbonitrile (crude mixture as precursor, ca. 70% purity), 0.27 g (1.82 mmol) of (1R,2S)-2,6-dimethyl-2,3-dihydro-1H-inden-1-amine and 0.34 g (2.42 mmol) of potassium carbonate is heated in 1 ml of N-methylpyrrolidone as solvent at 150° C. for 60 minutes in a microwave appliance (Biotage Initiator, http://www.biotage.com/DynPage.aspx?id=22001). The crude mixture is absorbed on silica gel and, following column chromatographic separation, 0.291 g of 2-amino-4-phenyl-6-[(1R)-1,2,3,4-tetrahydronaphthalen-1-ylamino]pyrimidine-5-carbonitrile is obtained (solid, 67% yield, 95% purity).

Provenance & Evidence