HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropyl iodide → HCID 66934326, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropyl iodide | HCID 6362 | — |
| Reactant | 2(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl- | HCID 81646 | — |
| Reactant | 2,2-Dimethylcyclohexan-1-one | HCID 136929 | — |
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | HCID 66934379 | HCID 66934379 | — |
| Product | HCID 66934326 | HCID 66934326 | 78% |
Reaction Steps
As described in Example 3 for preparation of 5-isopropyl-2,2-dimethylcyclopentanone, from 2,2-dimethylcyclohexanone (12.6 g, 110 mmol), lithium diisopropylamide solution (2 M in THF, 55.0 ml, 110 mmol), DMPU (14.1 g, 110 mmol) and 2-iodopropane (25.5 g, 150 mmol), 6-isopropyl-2,2-dimethylcyclohexanone (13.1 g, 78%) was obtained after standard workup and purification by silica gel FC (pentane/Et2O, 6:4, Rf=0.26).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445424B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-2afb819559994704aa1bd3f346a4f3b2 |
| Source note | uspto-grants-2013_05 |