HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoroaniline → 4-(((2-Fluorophenyl)amino)methyl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoroaniline | HCID 9584 | — |
| Reactant | 4-Formylbenzoic acid | HCID 12088 | — |
| Reactant | HCID 178419135 | HCID 178419135 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(((2-Fluorophenyl)amino)methyl)benzoic acid | HCID 39348539 | 99.2% |
Reaction Steps
A mixture of 4-formylbenzoic acid 47a (3.33 mmol, 500 mg), 2-fluoroaniline 47b (3.33 mmol, 370 mg), and decaborane (1 mmol, 122 mg) in 8 mL of MeOH was stirred at room temperature for 15 min. The mixture was concentrated and purified by preparative reverse-phase chromatography to afford 0.81 g (99%) of 47c.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445477B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-79f61a134d95455aaa2496f2e6fbccd7 |
| Source note | uspto-grants-2013_05 |