HuagongsheHuagongshe Chemistry Print Report · For research reference only
Butyl bromide → 2-(9-butyl-2-chloro-6-morpholino-9H-purin-8-yl)propan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Butyl bromide | HCID 8002 | — |
| Reactant | HCID 178458928 | HCID 178458928 | — |
| Product | 2-(9-butyl-2-chloro-6-morpholino-9H-purin-8-yl)propan-2-ol | HCID 58015212 | — |
Reaction Steps
2-(2-Chloro-6-morpholino-9H-purin-8-yl)propan-2-ol 100 mg was treated with bromobutane via General Procedure C to give crude intermediate 2-(9-butyl-2-chloro-6-morpholino-9H-purin-8-yl)propan-2-ol which was treated with 2-aminopyrimidine-5-boronic acid, pinacol ester via General Procedure A and was purified via reverse phase HPLC to give 55 mg of 103 as a white solid. MS (Q1) 413.3 (M)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445487B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-741a1f1cbb05426db1a45598879ce6d2 |
| Source note | uspto-grants-2013_05 |