(R)-3-Pyrrolidinol → HCID 44545043, compound

HRID 2093395Notes

Reaction equation

HRID 2093395 reaction equation
C(OC([NH:8][C:9]1[N:14]=[CH:13][C:12]([C:15]2[N:23]=[C:22]3[C:18]([N:19]=[CH:20][N:21]3[CH2:24][CH2:25][C:26](O)=[O:27])=[C:17]([N:29]3[CH2:34][CH2:33][O:32][CH2:31][CH2:30]3)[N:16]=2)=[CH:11][N:10]=1)=O)(C)(C)C.[NH:35]1[CH2:39][CH2:38][C@@H:37]([OH:40])[CH2:36]1>>[NH2:8][C:9]1[N:10]=[CH:11][C:12]([C:15]2[N:23]=[C:22]3[C:18]([N:19]=[CH:20][N:21]3[CH2:24][CH2:25][C:26]([N:35]3[CH2:39][CH2:38][C@@H:37]([OH:40])[CH2:36]3)=[O:27])=[C:17]([N:29]3[CH2:34][CH2:33][O:32][CH2:31][CH2:30]3)[N:16]=2)=[CH:13][N:14]=1

Participants

3

Reactant 2

HCID 2759337(R)-3-PyrrolidinolHCID 66909826HCID 66909826, compound

Product 1

HCID 44545043HCID 44545043, compound

Procedure

3-(2-(2-(Tert-butoxycarbonylamino)pyrimidin-5-yl)-6-morpholino-9H-purin-9-yl)propanoic acid (50 mg) was reacted with (R)-pyrrolidin-3-ol via General Procedure F followed by Boc deprotection via General Procedure E to give 10.9 mg 109 as white solid following reverse phase purification. MS (Q1) 440.2 (M)+

Workup

  1. customto give
  2. custom10.9 mg 109 as white solid following reverse phase purification

Sources & evidence

ORD record
ord-e36a6480003d4c02b6c91bb901e4ce7c
Source dataset
uspto-grants-2013_05
Patent number
US08445487B2

Reaction notes

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