HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Aminopyrimidin-5-yl)boronic acid → 5-(9-methyl-6-morpholino-9H-purin-2-yl)pyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Aminopyrimidin-5-yl)boronic acid | HCID 17750211 | — |
| Reactant | 2-Chloro-9-methyl-6-(4-morpholinyl)-9H-purine | HCID 71500687 | — |
| Product | 5-(9-methyl-6-morpholino-9H-purin-2-yl)pyrimidin-2-amine | HCID 44543764 | — |
Reaction Steps
4-(2-Chloro-9-methyl-9H-purin-6-yl)morpholine (95 mg) was reacted with 2-aminopyrimidine-5-boronic acid, pinacol ester via General Procedure A and purified via reverse phase HPLC to give 26.1 mg of 127 as a white solid. MS (Q1) 313.2 (M)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445487B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-8d64afac779848e59de18bda8575ca62 |
| Source note | uspto-grants-2013_05 |