5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine → HCID 44543765, compound

HRID 2093407Notes

Reaction equation

HRID 2093407 reaction equation
Cl[C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH3:11])=[C:4]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[N:3]=1.CC1(C)C(C)(C)OB([C:26]2[CH:27]=[CH:28][C:29]([NH2:32])=[N:30][CH:31]=2)O1>>[CH3:11][N:8]1[CH:7]=[N:6][C:5]2[C:9]1=[N:10][C:2]([C:26]1[CH:27]=[CH:28][C:29]([NH2:32])=[N:30][CH:31]=1)=[N:3][C:4]=2[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 27565555-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amineHCID 715006872-Chloro-9-methyl-6-(4-morpholinyl)-9H-purine

Product 1

HCID 44543765HCID 44543765, compound

Procedure

4-(2-Chloro-9-methyl-9H-purin-6-yl)morpholine (20 mg) was reacted with 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine via General Procedure A and purified via reverse phase HPLC to give 9.3 mg of 128 as a white solid. MS (Q1) 312.3 (M)+.

Workup

  1. custompurified via reverse phase HPLC

Sources & evidence

ORD record
ord-ee5422b52b8148d08328f29c626adeea
Source dataset
uspto-grants-2013_05
Patent number
US08445487B2

Reaction notes

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