HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 2-(2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)propan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | HCID 178458928 | HCID 178458928 | — |
| Product | 2-(2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)propan-2-ol | HCID 58015213 | — |
Reaction Steps
2-(2-Chloro-6-morpholino-9H-purin-8-yl)propan-2-ol (100 mg) was treated with iodomethane via General Procedure C to give crude intermediate 2-(2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)propan-2-ol which was treated with 2-aminopyrimidine-5-boronic acid, pinacol ester via General Procedure A and purified via reverse phase HPLC to give 44 mg of 130 as a white solid. MS (Q1) 371.2 (M)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445487B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-95e6472ac8bb4d4cb67e86c46a4c30c4 |
| Source note | uspto-grants-2013_05 |