HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isobutyl iodide → 3-(9-isobutyl-6-morpholino-9H-purin-2-yl)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isobutyl iodide | HCID 10556 | — |
| Reactant | 4-(2-chloro-9H-purin-6-yl)morpholine | HCID 3274603 | — |
| Reactant | [2-Tert-butyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl] carbonate | HCID 53421896 | — |
| Reactant | 2-Chloro-9-isobutyl-6-morpholin-4-yl-9H-purine | HCID 58015219 | — |
| Product | 3-(9-isobutyl-6-morpholino-9H-purin-2-yl)phenol | HCID 44544109 | — |
Reaction Steps
4-(2-Chloro-9H-purin-6-yl)morpholine (75 mg) was reacted with 1-iodo-2-methylpropane via General Procedure C. 4-(2-Chloro-9-isobutyl-9H-purin-6-yl)morpholine was reacted with 150 mg tert-butyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl carbonate via General Procedure A and purified via reverse phase HPLC to give 62.6 mg of 145 as a white solid. MS (Q1) 354.2 (M)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445487B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-03d49c1b95dc43f7ac8d7913fae22afc |
| Source note | uspto-grants-2013_05 |