HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2093459Generated: October 31, 2026
Methylamine → Tert-butyl 1'-[6-(methylamino)pyrimidin-4-yl]-4,4'-bipiperidine-1-carboxylate
https://huagongshe.com/reaction/2093459
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | HCID 59178818 | HCID 59178818 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Tert-butyl 1'-[6-(methylamino)pyrimidin-4-yl]-4,4'-bipiperidine-1-carboxylate | HCID 59178837 | — |
Reaction Steps
The tert-butyl 1′-(6-chloropyrimidin-4-yl)-4,4′-bipiperidine-1-carboxylate (19 mg, 0.05 mmol) was added to methyl amine in MeOH (1N, 2 mL) in a sealed bottle and heated to 50° C. for 2 days. The reaction crude were cooled down to r.t. and concentrated on rotavapor. The crude mixture was purified by preparative TLC with 10% methanol: dichloromethane to yield title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08445499B2 |
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| Source dataset | uspto-grants-2013_05 |
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| ORD ID | ord-05527008a37240ab9b135666975dbe17 |
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| Source note | uspto-grants-2013_05 |
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