Chloroacetone → HCID 59178925, compound

HRID 2093483Notes

Reaction equation

HRID 2093483 reaction equation
Cl[CH2:2][C:3]([CH3:5])=O.[NH2:6][C:7]([N:9]1[CH2:14][CH2:13][CH:12]([CH:15]2[CH2:20][CH2:19][N:18]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:17][CH2:16]2)[CH2:11][CH2:10]1)=[S:8]>C(O)C>[CH3:5][C:3]1[N:6]=[C:7]([N:9]2[CH2:10][CH2:11][CH:12]([CH:15]3[CH2:20][CH2:19][N:18]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:17][CH2:16]3)[CH2:13][CH2:14]2)[S:8][CH:2]=1

Participants

4

Reactant 2

HCID 6571ChloroacetoneHCID 59178824HCID 59178824, compound

Product 1

HCID 59178925HCID 59178925, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
75 °C

Procedure

The 1-chloroacetone (57 mg, 0.61 mmol) and tert-butyl 1′-(aminocarbonothioyl)-4,4′-bipiperidine-1-carboxylate (prepared as for Example 175, step 1) (200 mg, 0.61 mmol) were dissolved in ethanol (1.2 ml) and heated at 75° C. overnight. The solution was cooled to RT, and the solvent removed in vac. The residue was used in the subsequent procedure without further purification.

Workup

  1. temperatureThe solution was cooled to RT
  2. customthe solvent removed in vac
  3. customThe residue was used in the subsequent procedure without further purification

Sources & evidence

ORD record
ord-31c41f40ee214fba94fe497b4950d38a
Source dataset
uspto-grants-2013_05
Patent number
US08445499B2

Reaction notes

Loading…