反应详情

The above methyl 5-chloro-4-methoxy-6-methylnicotinate (1.0 g) was dissolved in 30 ml of methanol, and sodium borohydride (1.75 g) was then added to the solution. The resulting mixture was heated under reflux for 1 hour. Thereafter, a saturated ammonium chloride aqueous solution was added to the reaction solution under cooling on ice, followed by extraction with chloroform three times. The organic layer was dried over anhydrous sodium sulfate, and the solvent was then distilled away, so as to obtain the title compound (0.92 g) as an oily substance.

1. temperatureThe resulting mixture was heated
2. temperatureunder reflux for 1 hour
3. temperatureunder cooling on ice
4. extractionfollowed by extraction with chloroform three times
5. dry with materialThe organic layer was dried over anhydrous sodium sulfate
6. distillationthe solvent was then distilled away