Thionyl Chloride → HCID 58201184, compound

HRID 2093542Notes

Reaction equation

HRID 2093542 reaction equation
[Cl:1][C:2]1[C:3]([O:11][CH3:12])=[C:4]([CH2:9]O)[CH:5]=[N:6][C:7]=1[CH3:8].S(Cl)([Cl:15])=O>C(Cl)(Cl)Cl>[Cl:1][C:2]1[C:7]([CH3:8])=[N:6][CH:5]=[C:4]([CH2:9][Cl:15])[C:3]=1[O:11][CH3:12]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 58201212(5-Chloro-4-methoxy-6-methylpyridin-3-yl)methanol

Product 1

HCID 58201184HCID 58201184, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The above (5-chloro-4-methoxy-6-methylpyridin-3-yl)methanol (520 mg) was dissolved in 20 ml of chloroform, and thionyl chloride (0.38 ml) was then added to the solution under cooling on ice. The resulting mixture was stirred at the same temperature as above for 3 hours. Thereafter, the reaction solution was concentrated, and ethyl acetate was then added to the concentrate. The resulting mixture was washed with saturated sodium bicarbonate solution, water, and

Workup

  1. temperatureunder cooling on ice
  2. concentrationThereafter, the reaction solution was concentrated
  3. additionethyl acetate was then added to the concentrate
  4. washThe resulting mixture was washed with saturated sodium bicarbonate solution, water

Sources & evidence

ORD record
ord-da62c164068940748e8a3b7e2065babd
Source dataset
uspto-grants-2013_05
Patent number
US08445504B2

Reaction notes

Loading…