反应详情

The above (5-chloro-4-methoxy-6-methylpyridin-3-yl)methanol (520 mg) was dissolved in 20 ml of chloroform, and thionyl chloride (0.38 ml) was then added to the solution under cooling on ice. The resulting mixture was stirred at the same temperature as above for 3 hours. Thereafter, the reaction solution was concentrated, and ethyl acetate was then added to the concentrate. The resulting mixture was washed with saturated sodium bicarbonate solution, water, and

1. temperatureunder cooling on ice
2. concentrationThereafter, the reaction solution was concentrated
3. additionethyl acetate was then added to the concentrate
4. washThe resulting mixture was washed with saturated sodium bicarbonate solution, water