Acetic Anhydride → HCID 58201210, compound

HRID 2093554Notes

Reaction equation

HRID 2093554 reaction equation
[Cl:1][C:2]1[C:3]([CH3:11])=[N+:4]([O-])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[C:12]([O:15]C(=O)C)(=[O:14])[CH3:13]>>[C:12]([O:15][CH2:11][C:3]1[C:2]([Cl:1])=[C:7]([O:8][CH3:9])[CH:6]=[CH:5][N:4]=1)(=[O:14])[CH3:13]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 13682775HCID 13682775, compound

Product 1

HCID 58201210HCID 58201210, compound

Procedure

The above 3-chloro-4-methoxy-2-methylpyridin-1-oxide (890 mg) was dissolved in acetic anhydride (12 mL), and the resulting solution was then heated under reflux for 30 minutes. After leaving to cool to room temperature, the reaction solution was concentrated under reduced pressure, and the residue was then purified by silica gel chromatography (hexane-ethyl acetate), so as to obtain the title compound (576 mg) as an oily substance.

Workup

  1. temperaturethe resulting solution was then heated
  2. temperatureunder reflux for 30 minutes
  3. customAfter leaving
  4. concentrationthe reaction solution was concentrated under reduced pressure
  5. customthe residue was then purified by silica gel chromatography (hexane-ethyl acetate)

Sources & evidence

ORD record
ord-b48613c461ed4c5aa27a5af2d23a9cd3
Source dataset
uspto-grants-2013_05
Patent number
US08445504B2

Reaction notes

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