反应详情

Lopinavir (10 gm) was dissolved in dichloromethane (90 ml), methylenedichloride layer was dried over sodium sulfate and distilled off the solvent under vacuum at 45 deg C. to obtain residue. To the residue was added cyclohexane (50 ml), distilled off the solvent and the residue was collected. The residue obtained was taken in cyclohexane (70 ml), stirred for 60 hours at 20-25 deg C., filtered, washed the solid with cyclohexane (20 ml) and dried at 55-60 deg C. for 4 hours to obtain 9.5 gm of lopinavir cyclohexane solvate.

1. dry with materialmethylenedichloride layer was dried over sodium sulfate
2. distillationdistilled off the solvent under vacuum at 45 deg C
3. customto obtain residue
4. distillationdistilled off the solvent
5. customthe residue was collected
6. customThe residue obtained
7. filtration, filtered
8. washwashed the solid with cyclohexane (20 ml)
9. customdried at 55-60 deg C