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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2093561Generated: November 1, 2026

5-Nitro-3-(trifluoromethyl)-2-pyridinecarbonitrile → 5-Amino-3-(trifluoromethyl)pyridine-2-carbonitrile

https://huagongshe.com/reaction/2093561

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Nitro-3-(trifluoromethyl)-2-pyridinecarbonitrileHCID 21874893—
ReactantHCID 178418361HCID 178418361—
CatalystNickelHCID 935—
Product5-Amino-3-(trifluoromethyl)pyridine-2-carbonitrileHCID 13532246—

Reaction Steps

Alternatively, 2-cyano-3-(trifluoromethyl)-5-nitropyridine A10 can be reacted with hydrogen over Raney-Ni to obtain 2-cyano-3-(trifluoromethyl)-5-aminopyridine, A11.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08445507B2
Source datasetuspto-grants-2013_05
ORD IDord-3b61edfbe25043458ee0b15827874cbd
Source noteuspto-grants-2013_05