HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,10-Phenanthroline → 5-Nitro-3-(trifluoromethyl)-2-pyridinecarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,10-Phenanthroline | HCID 1318 | — |
| Reactant | 2-Bromo-5-nitro-3-(trifluoromethyl)pyridine | HCID 53486350 | — |
| Reactant | HCID 178418546 | HCID 178418546 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 5-Nitro-3-(trifluoromethyl)-2-pyridinecarbonitrile | HCID 21874893 | 67% |
Reaction Conditions
| Temperature | 160 °C |
|---|
Reaction Steps
The crude 2-bromo-5-nitro-3-(trifluoromethyl)pyridine 21 is dissolved in dimethylacetamide (DMA) and phenanthroline (0.2 equivalents) is added. The mixture is heated to 160° C. and CuCN (2 equivalents) is added. The mixture is stirred for 40 minutes. Chromatography is performed to produce the 5-nitro-3-(trifluoromethyl)pyridine-2-carbonitrile 22 in a yield of 67%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445507B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-da65ae6c13e64b979468e592764c11b2 |
| Source note | uspto-grants-2013_05 |