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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2093571Generated: October 30, 2026

5-Nitro-3-(trifluoromethyl)-2-pyridinecarbonitrile → 5-Amino-3-(trifluoromethyl)pyridine-2-carbonitrile

https://huagongshe.com/reaction/2093571

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Nitro-3-(trifluoromethyl)-2-pyridinecarbonitrileHCID 21874893—
CatalystIronHCID 23925—
SolventAcetic AcidHCID 176—
Product5-Amino-3-(trifluoromethyl)pyridine-2-carbonitrileHCID 1353224691%

Reaction Steps

A mixture of 5-nitro-3-(trifluoromethyl)pyridine-2-carbonitrile 22 and iron powder in acetic acid is heated. 5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile, 8 is obtained in a yield of 91%.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08445507B2
Source datasetuspto-grants-2013_05
ORD IDord-3608373715fe4aaa85ecb03b83671298
Source noteuspto-grants-2013_05