Trifluoroacetic acid → HCID 68745182, compound

Participants

Reaction Steps

To a solution of tert-butyl(3R)-3-({[4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)benzoyl]amino}methyl)piperidine-1-carboxylate benzoxazole (201 mg, EXAMPLE 94) in 15 ml dichloromethane was added trifluoroacetic acid (5 ml). The mixture was stirred at room temperature for 30 min. The mixture was concentrated in vacuo, diluted with 40 ml of ethyl acetate, and basified by slow and cautious addition of 40 ml of saturated aqueous sodium carbonate. The phases were separated and the aqueous phase was extracted with 40 ml of ethyl acetate. The combined organic layers were dried over sodium sulfate, filtered, and concentrated in vacuo to provide the title compound (144 mg, 89%). Mass spectrum (ESI) 403.3 (M+1).

Provenance & Evidence