HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → ethyl (2R)-5-oxopyrrolidine-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | D-Pyroglutamic acid | HCID 439685 | — |
| Solvent | Sulfuric Acid | HCID 1118 | — |
| Product | ethyl (2R)-5-oxopyrrolidine-2-carboxylate | HCID 643508 | — |
Reaction Steps
To a solution of D-pyroglutamic acid (compound I-A, 20.4 g, 0.16 mol) in 100 mL of EtOH, 1.2 mL of conc. sulfuric acid was added. The mixture was heated under reflux overnight. Solvent was removed under reduced pressure to give (R)-ethyl 5-oxopyrrolidine-2-carboxylate (compound II-AA).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445503B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-2ecb5840ec594558a37db16c422bc1e2 |
| Source note | uspto-grants-2013_05 |