HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(1H-Imidazol-2-yl)pyrimidine → (R)-8-cyclopentyl-7-ethyl-5-methyl-2-(2-(pyrimidin-5-yl)-1H-imidazol-1-yl)-7,8-dihydropteridin-6(5H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(1H-Imidazol-2-yl)pyrimidine | HCID 22288416 | — |
| Reactant | (R)-2-Chloro-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one | HCID 24820413 | — |
| Product | (R)-8-cyclopentyl-7-ethyl-5-methyl-2-(2-(pyrimidin-5-yl)-1H-imidazol-1-yl)-7,8-dihydropteridin-6(5H)-one | HCID 58405429 | — |
Reaction Steps
The title compound was prepared similarly to the methods described in Example 77, with Intermediate B instead of Intermediate C and with 5-(1H-imidazol-2-yl)pyrimidine instead of 2-phenyl-1H-imidazole. LCMS: 405.2 m/z (M+H)+; ret. Time: 5.44 min (Analytical Method C).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445503B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-f03b4bcbe4b04939a6a3e942a602842f |
| Source note | uspto-grants-2013_05 |