Lithium Hydroxide → HCID 66583917, compound

Participants

Reaction Conditions

Reaction Steps

A 2M aq. LiOH sol. (10 ml) was added to a solution of 1.1 g (3.0 mmol) 4-methyl-2-neopentyl-7-(trifluoromethyl)quinoline-3-carboxylic acid ethyl ester in a MeOH/1,4-dioxane mixture (in each case 10 ml) and the mixture was subsequently heated to 80° C. for 72 h. The organic solvents were removed as far as possible in a vacuum and the obtained aqueous solution was washed with ether, adjusted to pH 2 with 2M hydrochloric acid and diluted with EtOAc. The organic phase was separated and washed with brine, dried over MgSO4 and concentrated in a vacuum. 0.8 g (2.5 mmol, 82%) 4-methyl-2-neopentyl-7-(trifluoromethyl)quinoline-3-carboxylic acid was obtained as a residue. The raw product was further converted without additional purification.

Provenance & Evidence