Ethyl 4-chloro-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylate → HCID 66867379, compound

HRID 2093852Notes

Reaction equation

HRID 2093852 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:10]2[N:11]=[CH:12][N:13]=[C:14](Cl)[C:9]=2[NH:8][CH:7]=1)=[O:5])[CH3:2].[CH:16]1([CH2:20][O:21][C:22]2[CH:30]=[CH:29][C:25]3[O:26][CH2:27][O:28][C:24]=3[C:23]=2B2OC(C)(C)C(C)(C)O2)[CH2:19][CH2:18][CH2:17]1>>[CH2:1]([O:3][C:4]([C:6]1[C:10]2[N:11]=[CH:12][N:13]=[C:14]([C:23]3[C:24]4[O:28][CH2:27][O:26][C:25]=4[CH:29]=[CH:30][C:22]=3[O:21][CH2:20][CH:16]3[CH2:17][CH2:18][CH2:19]3)[C:9]=2[NH:8][CH:7]=1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 52987614Ethyl 4-chloro-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylateHCID 66867707HCID 66867707, compound

Product 1

HCID 66867379HCID 66867379, compound

Procedure

Starting from 4-chloro-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid ethyl ester and 5-cyclobutylmethoxy-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzo[1,3]dioxole (example A30) the title compound is obtained as colorless solid.

Sources & evidence

ORD record
ord-651dd5d90a074062a7a59f70642d2621
Source dataset
uspto-grants-2013_05
Patent number
US08445501B2

Reaction notes

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