HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-chloro-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylate → 4-(2-Cyclopropylmethoxy-5-fluoro-phenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-chloro-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylate | HCID 52987614 | — |
| Reactant | 2-(2-(Cyclopropylmethoxy)-5-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | HCID 56923638 | — |
| Product | 4-(2-Cyclopropylmethoxy-5-fluoro-phenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid ethyl ester | HCID 66867390 | — |
Reaction Steps
Starting from 4-chloro-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid ethyl ester and 2-(2-cyclopropylmethoxy-5-fluoro-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (example A39) the title compound is obtained as colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445501B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-3f0db66569ce454abce9981e3e1d3745 |
| Source note | uspto-grants-2013_05 |