Ethyl 4-chloro-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylate → 4-(5-Ethoxy-benzo[1,3]dioxol-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid ethyl ester

HRID 2093863Notes

Reaction equation

HRID 2093863 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:10]2[N:11]=[CH:12][N:13]=[C:14](Cl)[C:9]=2[NH:8][CH:7]=1)=[O:5])[CH3:2].[CH2:16]([O:18][C:19]1[CH:27]=[CH:26][C:22]2[O:23][CH2:24][O:25][C:21]=2[C:20]=1B1OC(C)(C)C(C)(C)O1)[CH3:17]>>[CH2:1]([O:3][C:4]([C:6]1[C:10]2[N:11]=[CH:12][N:13]=[C:14]([C:20]3[C:21]4[O:25][CH2:24][O:23][C:22]=4[CH:26]=[CH:27][C:19]=3[O:18][CH2:16][CH3:17])[C:9]=2[NH:8][CH:7]=1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 52987614Ethyl 4-chloro-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylateHCID 668666275-Ethoxy-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzo[1,3]dioxole

Product 1

HCID 668676134-(5-Ethoxy-benzo[1,3]dioxol-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid ethyl ester

Procedure

Starting from 4-chloro-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid ethyl ester and 5-ethoxy-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzo[1,3]dioxole (example A31) the title compound is obtained as colorless solid.

Sources & evidence

ORD record
ord-c628f2f7882446c5acc3bb021a45ad92
Source dataset
uspto-grants-2013_05
Patent number
US08445501B2

Reaction notes

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