Ethyl 4-chloro-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylate → 4-(5-Propoxy-benzo[1,3]dioxol-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid ethyl ester

HRID 2093864Notes

Reaction equation

HRID 2093864 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:10]2[N:11]=[CH:12][N:13]=[C:14](Cl)[C:9]=2[NH:8][CH:7]=1)=[O:5])[CH3:2].[CH2:16]([O:19][C:20]1[CH:28]=[CH:27][C:23]2[O:24][CH2:25][O:26][C:22]=2[C:21]=1B1OC(C)(C)C(C)(C)O1)[CH2:17][CH3:18]>>[CH2:1]([O:3][C:4]([C:6]1[C:10]2[N:11]=[CH:12][N:13]=[C:14]([C:21]3[C:22]4[O:26][CH2:25][O:24][C:23]=4[CH:27]=[CH:28][C:20]=3[O:19][CH2:16][CH2:17][CH3:18])[C:9]=2[NH:8][CH:7]=1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 52987614Ethyl 4-chloro-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylateHCID 668665485-Propoxy-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzo[1,3]dioxole

Product 1

HCID 668676814-(5-Propoxy-benzo[1,3]dioxol-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid ethyl ester

Procedure

Starting from 4-chloro-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid ethyl ester and 5-propoxy-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzo[1,3]dioxole (example A32) the title compound is obtained as colorless solid.

Sources & evidence

ORD record
ord-428b9733c0ac4632b1e1d8e24a8d97b3
Source dataset
uspto-grants-2013_05
Patent number
US08445501B2

Reaction notes

Loading…