Ethyl 4-chloro-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylate → HCID 66867554, compound

HRID 2093866Notes

Reaction equation

HRID 2093866 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:10]2[N:11]=[CH:12][N:13]=[C:14](Cl)[C:9]=2[NH:8][CH:7]=1)=[O:5])[CH3:2].[CH3:16][O:17][CH2:18][CH2:19][O:20][C:21]1[CH:29]=[CH:28][C:24]2[O:25][CH2:26][O:27][C:23]=2[C:22]=1B1OC(C)(C)C(C)(C)O1>>[CH2:1]([O:3][C:4]([C:6]1[C:10]2[N:11]=[CH:12][N:13]=[C:14]([C:22]3[C:23]4[O:27][CH2:26][O:25][C:24]=4[CH:28]=[CH:29][C:21]=3[O:20][CH2:19][CH2:18][O:17][CH3:16])[C:9]=2[NH:8][CH:7]=1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 52987614Ethyl 4-chloro-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylateHCID 66867842HCID 66867842, compound

Product 1

HCID 66867554HCID 66867554, compound

Procedure

Starting from 4-chloro-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid ethyl ester and 5-(2-methoxy-ethoxy)-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzo[1,3]dioxole (example A34) the title compound is obtained as colorless solid.

Sources & evidence

ORD record
ord-f0ba0219f68d4e10b3d905036e46a439
Source dataset
uspto-grants-2013_05
Patent number
US08445501B2

Reaction notes

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