4-Amino-1-Boc-piperidine → HCID 66866566, compound

HRID 2093892Notes

Reaction equation

HRID 2093892 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[C:12]2[C:13]3[NH:20][CH:19]=[C:18]([C:21](O)=[O:22])[C:14]=3[N:15]=[CH:16][N:17]=2)[CH2:3][CH2:2]1.[C:24]([O:28][C:29]([N:31]1[CH2:36][CH2:35][CH:34]([NH2:37])[CH2:33][CH2:32]1)=[O:30])([CH3:27])([CH3:26])[CH3:25]>>[C:24]([O:28][C:29]([N:31]1[CH2:36][CH2:35][CH:34]([NH:37][C:21]([C:18]2[C:14]3[N:15]=[CH:16][N:17]=[C:12]([C:7]4[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=4[O:5][CH2:4][CH:1]4[CH2:2][CH2:3]4)[C:13]=3[NH:20][CH:19]=2)=[O:22])[CH2:33][CH2:32]1)=[O:30])([CH3:27])([CH3:25])[CH3:26]

Participants

3

Reactant 2

HCID 12682914-Amino-1-Boc-piperidineHCID 66866726HCID 66866726, compound

Product 1

HCID 66866566HCID 66866566, compound

Procedure

Starting from 4-(2-cyclopropylmethoxy-phenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid (example A78) and 4-amino-piperidine-1-carboxylic acid tert-butyl ester the title compound is obtained as colorless solid.

Sources & evidence

ORD record
ord-928116b8f0ca4ad797b6a1cb0ed56611
Source dataset
uspto-grants-2013_05
Patent number
US08445501B2

Reaction notes

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