(R)-(+)-1-Boc-3-aminopyrrolidine → HCID 66866009, compound

HRID 2093908Notes

Reaction equation

[CH2:1]([O:4][C:5]1[CH:13]=[CH:12][C:8]2[O:9][CH2:10][O:11][C:7]=2[C:6]=1[C:14]1[C:15]2[NH:22][CH:21]=[C:20]([C:23](O)=[O:24])[C:16]=2[N:17]=[CH:18][N:19]=1)[CH2:2][CH3:3].[C:26]([O:30][C:31]([N:33]1[CH2:37][CH2:36][C@@H:35]([NH2:38])[CH2:34]1)=[O:32])([CH3:29])([CH3:28])[CH3:27]>>[C:26]([O:30][C:31]([N:33]1[CH2:37][CH2:36][C@@H:35]([NH:38][C:23]([C:20]2[C:16]3[N:17]=[CH:18][N:19]=[C:14]([C:6]4[C:7]5[O:11][CH2:10][O:9][C:8]=5[CH:12]=[CH:13][C:5]=4[O:4][CH2:1][CH2:2][CH3:3])[C:15]=3[NH:22][CH:21]=2)=[O:24])[CH2:34]1)=[O:32])([CH3:29])([CH3:27])[CH3:28]

Participants

Reactant 2

HCID 854070(R)-(+)-1-Boc-3-aminopyrrolidine

HCID 66866098HCID 66866098, compound

Product 1

HCID 66866009HCID 66866009, compound

Procedure

Starting from 4-(5-propoxy-benzo[1,3]dioxol-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid (example A70) and commercially available (R)-3-amino-pyrrolidine-1-carboxylic acid tert-butyl ester the title compound was obtained as colorless solid.

Sources & evidence

ORD record: ord-4d797c9e2c5242f0a9f823fc3b5cdf93
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08445501B2

Reaction notes

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