4-AMINOPIPERIDINE-1-CARBOXYLIC ACID → HCID 66866120, compound

HRID 2093917Notes

Reaction equation

HRID 2093917 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[CH:11]=[C:10]([O:12][CH2:13][O:14][CH3:15])[C:9]([F:16])=[CH:8][C:7]=2[C:17]2[C:18]3[NH:25][CH:24]=[C:23]([C:26](O)=[O:27])[C:19]=3[N:20]=[CH:21][N:22]=2)[CH2:3][CH2:2]1.[NH2:29][CH:30]1[CH2:35][CH2:34][N:33]([C:36]([OH:38])=[O:37])[CH2:32][CH2:31]1>>[C:1]([O:37][C:36]([N:33]1[CH2:34][CH2:35][CH:30]([NH:29][C:26]([C:23]2[C:19]3[N:20]=[CH:21][N:22]=[C:17]([C:7]4[CH:8]=[C:9]([F:16])[C:10]([O:12][CH2:13][O:14][CH3:15])=[CH:11][C:6]=4[O:5][CH2:4][CH:1]4[CH2:2][CH2:3]4)[C:18]=3[NH:25][CH:24]=2)=[O:27])[CH2:31][CH2:32]1)=[O:38])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 4452624-AMINOPIPERIDINE-1-CARBOXYLIC ACIDHCID 66867512HCID 66867512, compound

Product 1

HCID 66866120HCID 66866120, compound

Procedure

Starting from 4-(2-cyclopropylmethoxy-5-fluoro-4-methoxymethoxy-phenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid (example A84) and commercially available 4-amino-piperidine-1-carboxylic acid the title compound is obtained as colorless foam.

Sources & evidence

ORD record
ord-9a0d88214e2c4976b2abb0495f970615
Source dataset
uspto-grants-2013_05
Patent number
US08445501B2

Reaction notes

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