Acetyl chloride → HCID 44205617, compound

HRID 2094006Notes

Reaction equation

HRID 2094006 reaction equation
Cl.[NH:2]1[CH2:7][CH2:6][CH:5]([NH:8][C:9]([C:11]2[C:15]3[N:16]=[CH:17][N:18]=[C:19]([C:20]4[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:21]=4[O:27][CH2:28][CH:29]4[CH2:31][CH2:30]4)[C:14]=3[NH:13][CH:12]=2)=[O:10])[CH2:4][CH2:3]1.[C:32](Cl)(=[O:34])[CH3:33]>>[C:32]([N:2]1[CH2:3][CH2:4][CH:5]([NH:8][C:9]([C:11]2[C:15]3[N:16]=[CH:17][N:18]=[C:19]([C:20]4[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:21]=4[O:27][CH2:28][CH:29]4[CH2:30][CH2:31]4)[C:14]=3[NH:13][CH:12]=2)=[O:10])[CH2:6][CH2:7]1)(=[O:34])[CH3:33]

Participants

3

Reactant 2

HCID 6367Acetyl chlorideHCID 66867801HCID 66867801, compound

Product 1

HCID 44205617HCID 44205617, compound

Procedure

Starting from 4-(2-cyclopropylmethoxy-5-fluoro-phenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid piperidin-4-ylamide hydrochloride (example A159) and acetyl chloride the title compound is obtained as colorless solid.

Sources & evidence

ORD record
ord-732c613a932d424da664929250574330
Source dataset
uspto-grants-2013_05
Patent number
US08445501B2

Reaction notes

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