Acetyl chloride → HCID 44205841, compound

HRID 2094016Notes

Reaction equation

HRID 2094016 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([NH:7][C:8]([C:10]2[C:14]3[N:15]=[CH:16][N:17]=[C:18]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=4[O:25][CH2:26][CH:27]4[CH2:29][CH2:28]4)[C:13]=3[NH:12][CH:11]=2)=[O:9])[CH2:3][CH2:2]1.[C:30](Cl)(=[O:32])[CH3:31]>>[C:30]([N:1]1[CH2:2][CH2:3][CH:4]([NH:7][C:8]([C:10]2[C:14]3[N:15]=[CH:16][N:17]=[C:18]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=4[O:25][CH2:26][CH:27]4[CH2:28][CH2:29]4)[C:13]=3[NH:12][CH:11]=2)=[O:9])[CH2:5][CH2:6]1)(=[O:32])[CH3:31]

Participants

3

Reactant 2

HCID 6367Acetyl chlorideHCID 66866760HCID 66866760, compound

Product 1

HCID 44205841HCID 44205841, compound

Procedure

Starting from 4-(2-cyclopropylmethoxy-phenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid piperidin-4-ylamide (example A162) and acetyl chloride the title compound is obtained as colorless solid.

Sources & evidence

ORD record
ord-0d9cdd1d0c1745558c59ff6acd458922
Source dataset
uspto-grants-2013_05
Patent number
US08445501B2

Reaction notes

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