Propionyl chloride → HCID 66866769, compound

HRID 2094057Notes

Reaction equation

[NH:1]1[CH2:5][CH2:4][C@@H:3]([NH:6][C:7]([C:9]2[C:13]3[N:14]=[CH:15][N:16]=[C:17]([C:18]4[C:26]5[O:25][CH2:24][O:23][C:22]=5[CH:21]=[CH:20][C:19]=4[O:27][CH2:28][CH3:29])[C:12]=3[NH:11][CH:10]=2)=[O:8])[CH2:2]1.[C:30](Cl)(=[O:33])[CH2:31][CH3:32]>>[C:30]([N:1]1[CH2:5][CH2:4][C@@H:3]([NH:6][C:7]([C:9]2[C:13]3[N:14]=[CH:15][N:16]=[C:17]([C:18]4[C:26]5[O:25][CH2:24][O:23][C:22]=5[CH:21]=[CH:20][C:19]=4[O:27][CH2:28][CH3:29])[C:12]=3[NH:11][CH:10]=2)=[O:8])[CH2:2]1)(=[O:33])[CH2:31][CH3:32]

Participants

Reactant 2

HCID 62324Propionyl chloride

HCID 66866941HCID 66866941, compound

Product 1

HCID 66866769HCID 66866769, compound

Procedure

Starting from 4-(5-ethoxy-benzo[1,3]dioxol-4-yl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid (R)-pyrrolidin-3-ylamide (example A176) and propionyl chloride the title compound was obtained as colorless solid.

Sources & evidence

ORD record: ord-bae7fdfd25404fddaf4038c23aa9a88c
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08445501B2

Reaction notes

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