HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Chlorocarbonyl)cyclopropyl acetate → 4-(2-Cyclopropylmethoxy-4-methoxy-phenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid {1-[1-(1-hydroxy-cyclopropyl)-methanoyl]-piperidin-4-yl}-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Chlorocarbonyl)cyclopropyl acetate | HCID 14319638 | — |
| Reactant | 4-(2-cyclopropylmethoxy-4-methoxy-phenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid piperidin-4-ylamide | HCID 66867684 | — |
| Product | 4-(2-Cyclopropylmethoxy-4-methoxy-phenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid {1-[1-(1-hydroxy-cyclopropyl)-methanoyl]-piperidin-4-yl}-amide | HCID 66865878 | — |
Reaction Steps
Starting from 4-(2-cyclopropylmethoxy-4-methoxy-phenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid piperidin-4-ylamide (example A152) and acetic acid 1-chlorocarbonyl-cyclopropyl ester the title compound is obtained as colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08445501B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-0ee9e912d5ab49eeacae7e5c8dbc8d01 |
| Source note | uspto-grants-2013_05 |