1-(Chlorocarbonyl)cyclopropyl acetate → HCID 66866256, compound

HRID 2094155Notes

Reaction equation

HRID 2094155 reaction equation
Cl.[NH:2]1[CH2:7][CH2:6][CH:5]([NH:8][C:9]([C:11]2[C:15]3[N:16]=[CH:17][N:18]=[C:19]([C:20]4[CH:25]=[C:24]([F:26])[C:23]([O:27][CH3:28])=[CH:22][C:21]=4[O:29][CH2:30][CH:31]4[CH2:33][CH2:32]4)[C:14]=3[NH:13][CH:12]=2)=[O:10])[CH2:4][CH2:3]1.Cl[C:35]([C:37]1([O:40]C(=O)C)[CH2:39][CH2:38]1)=[O:36]>>[OH:40][C:37]1([C:35]([N:2]2[CH2:3][CH2:4][CH:5]([NH:8][C:9]([C:11]3[C:15]4[N:16]=[CH:17][N:18]=[C:19]([C:20]5[CH:25]=[C:24]([F:26])[C:23]([O:27][CH3:28])=[CH:22][C:21]=5[O:29][CH2:30][CH:31]5[CH2:33][CH2:32]5)[C:14]=4[NH:13][CH:12]=3)=[O:10])[CH2:6][CH2:7]2)=[O:36])[CH2:39][CH2:38]1

Participants

3

Reactant 2

HCID 143196381-(Chlorocarbonyl)cyclopropyl acetateHCID 66867561HCID 66867561, compound

Product 1

HCID 66866256HCID 66866256, compound

Procedure

Starting from 4-(2-cyclopropylmethoxy-5-fluoro-4-methoxy-phenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid piperidin-4-ylamide hydrochloride (example A166) and acetic acid 1-chlorocarbonyl-cyclopropyl ester the title compound is obtained as colorless solid.

Sources & evidence

ORD record
ord-47fb9427df194b70907327368835a8fa
Source dataset
uspto-grants-2013_05
Patent number
US08445501B2

Reaction notes

Loading…