1-(Chlorocarbonyl)cyclopropyl acetate → HCID 178426821, compound

HRID 2094161Notes

Reaction equation

HRID 2094161 reaction equation
[NH2:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9]([C:11]2[C:15]3[N:16]=[CH:17][N:18]=[C:19]([C:20]4[CH:25]=[C:24]([CH3:26])[CH:23]=[CH:22][C:21]=4[O:27][CH2:28][CH:29]4[CH2:31][CH2:30]4)[C:14]=3[NH:13][CH:12]=2)=[O:10])[CH2:4][CH2:3]1.Cl[C:33]([C:35]1([O:38]C(=O)C)[CH2:37][CH2:36]1)=[O:34]>>[OH:38][C:35]1([C:33]([NH:1][C@H:2]2[CH2:7][CH2:6][C@H:5]([NH:8][C:9]([C:11]3[C:15]4[N:16]=[CH:17][N:18]=[C:19]([C:20]5[CH:25]=[C:24]([CH3:26])[CH:23]=[CH:22][C:21]=5[O:27][CH2:28][CH:29]5[CH2:30][CH2:31]5)[C:14]=4[NH:13][CH:12]=3)=[O:10])[CH2:4][CH2:3]2)=[O:34])[CH2:37][CH2:36]1

Participants

3

Reactant 2

HCID 143196381-(Chlorocarbonyl)cyclopropyl acetateHCID 178426820HCID 178426820, compound

Product 1

HCID 178426821HCID 178426821, compound

Procedure

Starting from trans-4-(2-cyclopropylmethoxy-5-methyl-phenyl)-5H-pyrrolo[3,2-d]pyrimidine-7-carboxylic acid (4-amino-cyclohexyl)-amide (example A170) and acetic acid 1-chlorocarbonyl-cyclopropyl ester the title compound is obtained as colorless solid.

Sources & evidence

ORD record
ord-d7d86fd8b0934e5b94e4ca6f3ef27bcf
Source dataset
uspto-grants-2013_05
Patent number
US08445501B2

Reaction notes

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